This review summarizes the recent developments in using QMAs in several regioselective transformations, including allylic substitution, multicomponent reactions, deoxyacylation, Wittig reaction, deuteration, aryloxylation, and [3+2] annulations. The review demonstrates that the production of C-C, C-X, C-P, and C-O bonds has significantly advanced with the invention of metal-free, cheap, and scalable techniques employing QMA as a starting material.